Tsunade (綱手) is the Fifth Hokage (五代目火影, Godaime Hokage) of Konohagakure, taking over after Hiruzen Sarutobi died; she was replaced by Danzō, however, after she went into a coma during Pain's invasion, having exerted all of her chakra to protect the citizens from the large-scale Shinra Tensei that destroyed the village. She recovers shortly after Kakashi Hatake become Sixth Hokage.
Tsunade is the only known living member of the Senju clan; she is directly descended from the First Hokage, her grandfather Hashirama Senju--and is related to the Second Hokage, her granduncle Tobirama Senju. Along with Orochimaru and Jiraiya, Tsunade is one of the Legendary Sannin of Konoha; and as of Jiraiya's death and Orochimaru's permanent sealing, Tsunade is the only one of her former teammates who is still alive.
Tsunade is the granddaughter of the First Hokage, and the grandniece of the Second Hokage, leading other characters to call her "Princess" (姫, Hime). She is, along with Jiraiya and Orochimaru, a former student of the Third Hokage Hiruzen Sarutobi. Tsunade is well-known for her extremely large breasts (106 centimeters, according to Jiraiya's estimate), despite the fact that Jiraiya referred to her as "flat-chested Tsunade" during their childhood. In addition, during a flashback, it is shown that Team Hiruzen underwent the same initial training as Team Kakashi, and had to capture bells from their sensei. The flashback shows Tsunade and Orochimaru were the ones to capture one bell each out of the two existent ones, while Jiraiya was tied to a pole.
During the Second Great Shinobi World War, Tsunade and her former teammates fought Hanzō, who gave them the title of Konoha's "Three Legendary Shinobi" (伝説の三忍, Densetsu no Sannin) as a reward for surviving the strife of their battle. On their way back to Konoha, they encountered the Ame Orphans, who Jiraiya chose to train. Throughout the war, she would become famous for frequently counteracting Chiyo's poisoning attempts, earning contempt from Chiyo because of it. Furthermore, according to Jiraiya, Tsunade was the one to bring them victory in the war.
At some point throughout, however, on her brother's twelfth birthday, Tsunade gave him their grandfather's crystal necklace, in the hopes that it would help him achieve his dream of becoming Hokage. The next day, he died as a casualty of the war, which returned the necklace to Tsunade's possession. Sometime afterwards, Tsunade fell in love with a man named Dan, who also wanted to become Hokage. As a sign of her affection, and in the hopes that it would help make his dreams come true, Tsunade gave him the amulet as well. Dan, too, would go on to die a bloody death during the course of the war, once again returning the necklace to her possession.
Just before Third Great Shinobi War, she took command of a team of Genin called Team Aoitori; consisting of Kyūka Namikaze, Riyan Uchiha, and a yet unnamed member. She was their sensei, teaching them basic medical ninjutsu; except for Riyan, who's chakra control was poor at the time. She also saw her students promoted to Chūnin, right before war broke out. She was present when Danzō killed Riyan's brother, Mataiden Uchiha. After he is exiled from the village by Danzō, and with the deaths of the two she loved the most, Tsunade came to lose faith in the title of Hokage, believing that only fools would want such a position. With these changes of ideals, Tsunade left Konoha with Dan's niece, Shizune, taking her in as her apprentice.
Although Tsunade is over fifty years old, she maintains a young appearance through a constant Transformation Technique. She has a violet rhombus on her forehead, a chakra gathering point known as the Yin Seal. Tsunade has fair skin and brown eyes. Except for her bangs, which are parted in the middle and fall down the sides of her face, Tsunade's long, blonde hair is tied into two ponytails using bands in the same colour as the seal on her forehead.
She often wears a grass-green robe with the kanji for gamble (賭, kake) written in black on the back, inside a red circle. Underneath she wears a khaki, kimono-style blouse with no sleeves, held closed by a broad, dark bluish-grey obi that matches her trousers. Her blouse is closed quite low, revealing her sizable cleavage.
She wears open-toed sandals with low heels and nail polish in the same color as her trousers and obi on both her fingernails and toenails. She used to wear the First Hokage's Necklace in clear view on her chest, before giving it to Naruto Uzumaki.